Current Workshop - Applications are now closed
Join us for a three-day hybrid workshop hosted by the Stanford-SLAC CryoEM Center, focused on modeling and structure validation in cryo-electron microscopy (cryoEM). With the growing number of cryoEM structures being solved and deposited, this workshop aims to provide practical guidance and hands-on insights into a variety of tools and approaches. Topics will include model building, refinement and visualization using programs (Coot, Phenix, ChimeraX, ISOLDE, and etc) for proteins and nucleic acids, as well as best practices for structure validation and deposition.
The program will feature expert-led lectures, live software demonstrations, and opportunities for interactive learning. Whether you're new to cryoEM modeling or looking to refine your workflows, this workshop is designed to support the structural biology community in generating accurate and reliable models.
Dr. Alexandre Cassago, SLAC
Stanford-SLAC CryoEM Center Modeling and Structure Validation Workshop October 28–30, 2025 | Hybrid (In-person at SLAC + Virtual)
Join us for a three-day hybrid workshop hosted by the Stanford-SLAC CryoEM Center, focused on modeling and structure validation in cryo-electron microscopy (cryoEM). With the growing number of cryoEM structures being solved and deposited, this workshop aims to provide practical guidance and hands-on insights into a variety of tools and approaches. Topics will include model building, refinement and visualization using programs (Coot, Phenix, ChimeraX, ISOLDE, and etc) for proteins and nucleic acids, as well as best practices for structure validation and deposition.The program will feature expert-led lectures, live software demonstrations, and opportunities for interactive learning. Whether you're new to cryoEM modeling or looking to refine your workflows, this workshop is designed to support the structural biology community in generating accurate and reliable models.
Workshop Agenda (Tentative)
| 8:30 AM | Registration & Check-In | ||
| 9:00 AM | Wah Chiu | Stanford University | Workshop Introduction |
| 9:15 AM | Nigel Moriarty | LBNL | Improvements for chemical accurate restraint |
| 10:45 AM | Coffee Break | ||
| 11:00 AM | Oleg Sobolev | LBNL | Model building and refinement in Phenix |
| 12:30 PM | Lunch | ||
| 1:30 PM | Rachael Kretsch | Stanford University | Overview of tools for nucleic acid structural modeling and validation |
| 3:00 PM | Coffee Break | ||
| 3:15 PM | In-Person Attendees | Participant Talks | |
| 5:00 PM | Dinner in in the Redwoods | Provided by Workshop | |
| 8:00 PM | End of Day |
| 8:30 AM | CryoEM Facility Tour Registration | ||
| 9:00 AM | Paul Emsley | MRC | Model-building, Refinement and Validation using Coot |
| 10:30 AM | Coffee Break | ||
| 10:45 AM | Lucrezia Catapano | MRC | Model-building, Refinement and Validation using Moorhen |
| 12:15 PM | Group Photo | ||
| 12:30 PM | Lunch in the Redwoods | Provided by Workshop | |
| 2:00 PM | Tom Goddard | UCSF | Creating Animations with ChimeraX |
| 3:15 PM | Coffee Break | ||
| 3:30 PM | Tristan Croll | Altos Lab | Interactive physics-based model building in ISOLDE |
| 5:00 PM | End of Day |
| 9:00 AM | Stephanie Wankowicz | Vanderbilt University | Modeling conformational and compositional heterogeneity in CryoEM Structures |
| 10:30 AM | Coffee Break | ||
| 10:45 AM | Jane Richardson | Duke University | How to get the most out of validation |
| 12:15 PM | Lunch Break | ||
| 1:30 PM | Greg Pintilie | Stanford University | 3DEM Map-Model Validation Using Q-Scores |
| 3:00 PM | Coffee Break | ||
| 3:15 PM | Stephen Burley w/Justin Flatt | RCSB Protein Data Bank, Rutgers, UCSD | Advancing FAIR and Sustainable 3DEM Data Ingestion, Validation, Management, and Distribution at the Worldwide Protein Data Bank |
| 4:45 PM | Closing Remarks | ||
| 5:15 PM | Facility Tour | ||
| 6:00 PM | End of Workshop |
